John E. CasidaProfessor of Toxicology Ph.D. (Biochemistry/Entomology), University of Wisconsin-Madison,1954 (510) 642-5424 |
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Pesticide Chemistry and Toxicology, Metabolism and Mode of Action of Organic Toxicants, Insect Biochemistry
Research in the Environmental Chemistry and Toxicology Laboratory emphasizes pesticide mode of action and metabolism. This information is important to optimize pesticide use, improve their selectivity and environmental characteristics, and minimize the hazards of exposure for humans, domestic animals, and other nontarget species. Recent research involves three closely related topics.
The first concerns insecticide action on the nicotinic, GABA and ryanodine receptors with particular attention to characterization of the binding sites in insects and mammals relative to selective action. The second topic characterizes the metabolites, metabolic pathways, and synergist-type inhibitors of pesticide chemical metabolism. Finally, the research attempts to define the secondary effects of pesticide action in mammals leading to adverse toxicology.
Most Recent Publications
Casida JE, 2012 The greening of pesticide–environment interactions: some personal observations. Environ Health Perspect. 2012. 120. 487-93.
Ruby MA, Nomura DK, Hudak CS, Barber A, Casida JE, Krauss RM. Acute overactive endocannabinoid signaling induces glucose intolerance, hepatic steatosis, and novel cannabinoid receptor 1 responsive genes. PLoS One. 2011. 6.
Ford KA, Gulevich AG, Swenson TL , Casida JE. Neonicotinoid Insecticides: oxidative stress in planta and metallo-oxidase inhibition. J. Agric. Food Chem. 2011. 59. 4860-7.
Nomura DK, Casida JE. Activity-based protein profiling of organophosphorus and thiocarbamate pesticides reveals multiple serine hydrolase targets in mouse brain. J. Agric. Food Chem. 2011. 59. 2808-15.
Tomizawa, M., Casida, J.E. Unique neonicotinoid binding conformations conferring selective receptor interactions. J. Agric. Food Chem. 2011. 59.2825-2828.
Watson GB, Loso MR, Babcock JM, Hasler JM, Letherer TJ, Young CD, Zhu Y, Casida JE, Sparks TC. Novel nicotinic action of the sulfoximine insecticide sulfoxaflor. Insect Biochem. Mol. Biol. 2011. 41. 432-9.
Chen L, Xue L, Giacomini KM, Casida JE. GABAA receptor open state conformation determines non-competitive antagonistic binding. Toxicol. Appl. Pharmacol. 2011. 250. 221-8.
Tomizawa M, Casida JE. Neonicotinoid insecticides: highlights of a symposium on strategic molecular designs. J. Agric. Food Chem. 2011. 59. 2883-6.
Ford KA, Casida JE, Chandran D, Gulevich AG, Okrent RA, Durkin KA, Sarpong R, Bunnelle EM, Wildermuth MC. Neonicotinoid insecticides induce salicylate-associated plant defense responses. Proc. Natl. Acad. Sci. USA, 2011. 107. 17527-32.
Tomizawa M, Kagabu S, Casida JE. Receptor structure-guided neonicotinoid design. J. Agric. Food Chem. 2011. 59. 2918-22.
Casida, J. E. Neonicotinoid metabolism: compounds, substituents, pathways, enzymes, organisms and relevance. J. Agric. Food Chem. 2011. 59. 2923-31.
Casida, J. E. Curious about pesticide action. J. Agric. Food Chem. 2011. 59.2762-9.
Casida JE. Michael Elliott’s billion dollar crystals and other discoveries in insecticide chemistry. Pest Manag. Sci. 2010. 66. 1163-70.
Casida, J. E., A. G. Gulevich, R. Sarpong and E. Bunnelle. S-Arachidonoyl-2-thioglycerol synthesis and use for fluorimetric and colorimetric assays of monoacylglycerol lipase. Bioorg. Med. Chem. 2010. 18. 1942-7.
Ohno, I., M. Tomizawa, K. A. Durkin, J.E. Casida and S. Kagabu. Bis-neonicotinoid insecticides: observed and predicted binding interactions with the nicotinic receptor. Bioorg. Med. Chem. Lett. 2009. 19. 3449-52.
Tomizawa, M., T. T. Talley, J. F. Park, D. Maltby, K. F. Medzihradszky, K. A. Durkin, J. M. Cornejo-Bravo, A. L. Burlingame, J. E. Casida, and P. Taylor. Nicotinic agonist binding site mapped by methionine and tyrosine-scanning coupled with azidochloropyridinyl photoaffinity labeling. J. Med. Chem. 2009. 52. 3735-41.
Shi, X., R. A. Dick, K. A. Ford and J. E. Casida. Enzymes and inhibitors in neonicotinoid insecticide metabolism. J. Agric. Food Chem. 2009. 57. 4861-6.
Casida, J.E. Pest toxicology: the primary mechanisms of pesticide action. Chem. Res. Toxicol. 2009. 22. 609-19.
Ohno, I., M. Tomizawa, K.A. Durkin, Y. Naruse, J.E. Casida and S. Kagabu. Neonicotinoid substituents forming a water bridge at the nicotinic acetylcholine receptor. J. Agric. Food Chem. 2009. 57. 2436-40.
Ohno, I., M. Tomizawa, K.A. Durkin, Y. Naruse, J.E. Casida and S. Kagabu. Molecular features of neonicotinoid pharmacophore variants interacting with the insect nicotinic receptor. Chem. Res. Toxicol. 2009. 22. 476-82.
Tomizawa, M. and J.E. Casida. Molecular recognition of neonicotinoid insecticides: the determinants of life or death. Acc. Chem. Res. 2009. 42. 260-269.