Ron KraussAdjunct Professor Director of Atherosclerosis Research at Children's Hospital Oakland Research Institute Senior Scientist in the Life Sciences Division of Lawrence Berkeley National Laboratory (510) 450-7908 |
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Genetic factors influencing plasma lipoprotein profiles and dietary responsiveness in humans. Metabolic behavior, physicochemical characteristics, and functional properties of low density lipoprotein (LDL) subclasses. Role of lipolytic enzymes and cell-surface receptors in lipoprotein metabolism. Gene-environment interactions underlying the cluster of coronary disease risk factors associated with small, dense LDL and insulin resistance.
The major focus of my laboratory is the identification and characterization of metabolic and genetic factors influencing plasma lipoprotein profiles and their response to dietary and drug interventions in humans. This involves the use of genomic tools as well as detailed phenotypic characterization for analysis of regulation and functional properties of atherogenic lipoproteins.
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Most Recent Publications
Shin, M.J., P.J. Blanche, R.S. Rawlings, H.S. Fernstrom, R.M. Krauss. Increased plasma concentration of lipoprotein (a) on a low fat, high carbohydrate diet is associated with increased plasma concentration of apolipoprotein CII bound to apoB-containing lipoproteins. Am J Clin Nutr 85:1527-32, 2007.
Mangravite, L.M., K. Dawson, R.R. Davis, J.P. Gregg, R.M. Krauss. Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and correlated with plasma triacylglycerol response. Am J Clin Nutr 86:759-767,2007.
Shin, M.J., Kanaya, A.M. and R.M. Krauss. Polymorphisms in the peroxisome proliferator activated receptor gene are associated with levels of apolipoprotein CIII and triglyceride in African-Americans but not Caucasians. Atherosclerosis 198:313-319, 2008.
Krauss, R.M., Mangravite L.M., Smith, J.D., Medina, M.W., Wang, D., Guo, X., Rieder, M.J., Simon, J.A., Hulley, S.B., Waters, D., Saad, M., Williams, P.T., Taylor, K.D., Yang, H., Nickerson, D.A. and Rotter, J.I. Variation in the Hydroxymethyl Glutaryl Coenzyme A Reductase Gene Is Associated With Racial Differences in Low-Density Lipoprotein Cholesterol Response to Simvastatin Treatment. Circulation 117:1537-1544, 2008.
Medina, M.W., Gao, F., Ruan, W., Rotter, J.I., and R.M. Krauss. Alternative splicing of HMGCR is associated with plasma LDL cholesterol response to simvastatin. Circulation [Epub ahead of print] 2008.