Ron KraussAdjunct Professor Director of Atherosclerosis Research at Children's Hospital Oakland Research Institute Senior Scientist in the Life Sciences Division of Lawrence Berkeley National Laboratory (510) 450-7908 |
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The overall aim of my program is to identify genetic, dietary, and pharmacologic influences on lipoprotein metabolism and related metabolic traits that influence risk for cardiovascular disease (CVD). Innovative genomic and molecular approaches are applied in humans and in cellular and model systems to derive information that can lead to improved prevention of CVD.
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Most Recent Publications
Ruby, M.A., Nomura, D.K., Hudak, C.S., Mangravite, L.M., Chiu, S., Casida, J.E., & Krauss, R.M. (2008). Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins. Proc. Natl. Acad. Sci. USA, 105, 14561-14566. PMCID: 18794527
Chasman, D.I., Paré, G., Zee, R.Y.L., Parker, A.N., Cook, N.R., Buring, J.E., Kwiatkowski, D.J., Rose, L.M., Smith, J.D., Williams, P.T., Rieder, M.J., Rotter, J.I., Nickerson, D.A., Krauss, R.M., Miletich, J.P., & Ridker, P.M. (2008). Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and apolipoprotein B among 6382 white women in genome-wide analysis with replication. Circ. Cardiovasc. Genet., 1, 21 - 30. PMCID: 9802338
Siri-Tarino, P., Williams, P.T., Fernstrom, H.S., Rawlings, R.S., & Krauss, R.M. (2009). Reversal of small, dense LDL subclass phenotype by normalization of adiposity. Obesity, 17, 1768-75. PMCID: 19498345
Musunuru, K., Orho-Melander, M., Caulfield, M.P., Li, S., Salameh, W.A., Reitz, R.E., Berglund, G., Hedblad, B., Engstrom, G., Williams, P.T., Kathiresan, S., Melander, O. & Krauss, R.M. (2009). Ion mobility analysis of liproprotein subfractions identified three independent axes of cardiovascular risk. Arterioscler Thromb Vasc Biol., 29, 1975-80. PMCID: 19729614
Siri-Tarino, P., Sun, Q., Hu, F. & Krauss, R.M.(2010). A meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Amer. J. Clin. Nutr., 91, 535-546. PMCID: 20071648
Shin, M.-J. and Krauss, R.M. (2010). Apolipoprotein CIII bound to apoB-containing lipoproteins is associated with small, dense LDL independent of plasma triglyceride levels in healthy men. Atherosclerosis, 211:337-341. PMID: 20303494
Barber, M.J., Mangravite, L.M., Hyde, C.L., Chasman, D.I., Smith, J.D., McCarty, C.A., Li, X., Wilke, R.A., Rieder, M.J., Williams, P.T., Ridker, P.M., Chatterjee A., Rotter, J.I., Nickerson, D.A., Stephens, M. and Krauss, R.M. (2010). Genome-wide association of lipid-lowering response to statins in combined study populations. PLoS ONE, 5: e9763. PMID: 20339536, PMCID: PMC2842298
Henderson, G.C., Krauss, R.M., Fattor, J.A., Faghihnia, N., and Luke-Zeitou, M., (2010). Plasma triglyceride concentrations are rapidly reduced following individual bouts of endurance exercise in women. Eur. J. Appl. Physiol., 109:721-30. PMCID: PMC2883923, NIHMS195828.
Mangravite, L.M., Medina, M.W., Cui, J., Pressman, S., Smith, J.D., Rieder, M.J., Guo, X., Nickerson, D.A., Rotter, J.I., and Krauss, R.M. (2010). Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin. Arterioscler. Thromb., 30:1485-92. PMID: 20413733, NIHMS203361
Musunuru, K., Strong, A., Frank-Kamenetsky, M., Lee, N.E., Ahfeldt, T., Sachs, K.V., Li, X., Li, H., Kuperwasser, N., Ruda, V.M., Pirruccello, J.J., Muchmore, B., Prokunina-Olsson, L., Hall, J.L., Schadt, E.E., Morales, C.R., Lund-Katz, S., Phillips, M.C., Wong, J., Cantley W., Ejebe, K.G., Orho-Melander, M., Melander, O., Koteliansky, V., Fitzgerald, K., Krauss, R.M., Cowan, C.A., Kathiresan, S., and Rader, D.J. (2010). From Noncoding Variant to Phenotype via SORT1 at the 1p13 Cholesterol Locus. Nature, 466: 714-719. PMID: 20696566
Teslovich, T.M., Musunusru, K., Smith, A.V., Edmondson, A.C., et al. (2010). Biological, Clinical and Population Relevance of 95 Loci for Blood Lipids. Nature, 466, 707-713. PMID: 20686565
Siri-Tarino, P.W., Woods, A., Bray, G.A. and Krauss, R.M. (2010). Reversal of Small, Dense LDL Subclass Phenotype by Weight Loss Is Associated With Impaired Fat Oxidation. Obesity (Silver Spring). [Epub ahead of print]. PMID: 20559299
Ruby, M.A., Goldenson, B., Orasanu, G., Johnston, T.P., Plutzky, J. and Krauss, R.M. (2010). VLDL hydrolysis by LpL activates PPAR-(alpha) through generation of unbound fatty acids. (2010). J. Lipid. Res., 51:2275-81. PMID: 20421589
Kaddurah-Daouk, R., Baillie R.A., Zhu, H., Zeng, Z.B., Wiest, M.M., Nguyen, U.T., Watkins, S.M. and Krauss, R.M. (2010). Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study. Metabolomics, 6:191-201. PMCID: PMC2862962
Faghihnia, N., Tsimikas, S., Miller, E.R., Witztum, J.L., Krauss, R.M. (2010). Changes in lipoprotein(a), oxidized phospholipids and LDL subclasses with a low-fat, high-carbohydrate diet. J. Lipid Res. 51:3324-30. PMID: 20713651ss.
Medina, M.W., Gao, F., Naidoo, D., Rudel, L.L., Temel, R.E., McDaniel, A.L., Marshall, S.M. and Krauss, R.M. (2011). Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake. PLoS One. 6:e19420. PMID: 21559365.
Shin, M.J., P.J. Blanche, R.S. Rawlings, H.S. Fernstrom, R.M. Krauss. Increased plasma concentration of lipoprotein (a) on a low fat, high carbohydrate diet is associated with increased plasma concentration of apolipoprotein CII bound to apoB-containing lipoproteins. Am J Clin Nutr 85:1527-32, 2007.
Mangravite, L.M., K. Dawson, R.R. Davis, J.P. Gregg, R.M. Krauss. Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and correlated with plasma triacylglycerol response. Am J Clin Nutr 86:759-767,2007.
Shin, M.J., Kanaya, A.M. and R.M. Krauss. Polymorphisms in the peroxisome proliferator activated receptor gene are associated with levels of apolipoprotein CIII and triglyceride in African-Americans but not Caucasians. Atherosclerosis 198:313-319, 2008.
Krauss, R.M., Mangravite L.M., Smith, J.D., Medina, M.W., Wang, D., Guo, X., Rieder, M.J., Simon, J.A., Hulley, S.B., Waters, D., Saad, M., Williams, P.T., Taylor, K.D., Yang, H., Nickerson, D.A. and Rotter, J.I. Variation in the Hydroxymethyl Glutaryl Coenzyme A Reductase Gene Is Associated With Racial Differences in Low-Density Lipoprotein Cholesterol Response to Simvastatin Treatment. Circulation 117:1537-1544, 2008.
Medina, M.W., Gao, F., Ruan, W., Rotter, J.I., and R.M. Krauss. Alternative splicing of HMGCR is associated with plasma LDL cholesterol response to simvastatin. Circulation [Epub ahead of print] 2008.