Joseph L. NapoliProfessor Chair of Nutritional Science and Toxicology Department Chair Graduate Group in Nutrition Ph.D. Medicinal Chemistry University of Michigan, 1975 (510) 642-5202 |
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Retinoid Function and Endocrinology
All vertebrates require atRA and 9cRA for reproduction, growth, nervous system development and function, energy balance and weight control, and immune function. Retinol (vitamin A) serves as the precursor for atRA and 9cRA. This lab studies regulation of the molecular apparatus that generates atRA and 9cRA from retinol, and the function of atRA and 9cRA in the nervous system and in modulating intermediary metabolism (energy balance), thereby affecting memory, appetite, adiposity and body size.
Most Recent Publications
N. Chen, B. Onisko, J.L. Napoli. (2008). The nuclear transcription factor RARα associates with neuronal RNA granules and suppresses translation. J. Biol. Chem. 283, 20841-20847.
M.A. Kane, A.E. Folias, J.L. Napoli. (2008). HPLC/UV quantitation of retinal, retinol, and retinyl esters in serum and tissues. Anal. Biochem. 378, 71-79.
M.A. Kane, A.E. Folias, C. Wang, J.L. Napoli. (2008). Quantitative profiling of endogenous retinoic acid in vivo and in vitro by tandem mass spectrometry. Anal. Chem. 80, 1702-1708.
N. Chen, J.L. Napoli (2008). All-trans-retinoic acid stimulates translation and induces spine formation in hippocampal neurons through a membrane-associated RARα. FASEB J. 22, 236-245.
K. M. Kransler, D. A. Tonucci, B. P. McGarrigle, J. L. Napoli, J. R. Olson. (2007). Gestational Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters retinoid homeostasis in maternal and perinatal tissues of the Holtzman rat. Toxicol. Appl. Pharmacol. 224, 29-38.
M. Zhang, P. Hu, C.R. Krois, M.A. Kane, J.L. Napoli (2007). Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse. FASEB J. 21, 2886-2896.
P. Hu, M. Zhang, J.L. Napoli. (2007). Ontogeny of rdh9 (Crad3) expression: ablation causes changes in retinoid and steroid metabolizing enzymes, but RXR and androgen signalling seem normal. Biochim. Biophysica Acta, 1770, 694-705.