Barry ShaneProfessor Professor and Nutritionist in the Agricultural Experiment Station Ph.D. (Biochemistry), University of London, 1970 (510) 643-6692 |
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The major research efforts of my laboratory are in the area of biochemical nutrition and, in particular, the control of one carbon metabolism. We investigate experimental nutrition problems at a basic molecular or cellular level to obtain a better understanding of factors that influence nutritional requirements and how this varies among the population. We study how genetic variation in the pathways of one carbon metabolism influence chronic disease risk and susceptibility to birth defects using humans and genetically modified animal models.
Most Recent Publications
O’Leary, V. B., Mills, J. L., Pangilinan, F., Kirke, P. N., Cox, C., Conley, M., Weiler, A., Peng, K., Shane, B., Scott, J. M., Parle-McDermott, A., Molloy, A. M., Brody, L. C., Members of the Birth Defects Research Group. (2005). Analysis of methionine synthase reductase polymorphisms for neural tube defects risk association. Molec. Genet. Metab. 85:220-227.
Lim, U., Peng, K., Shane, B., Stover, P. J., Litonjua, A. A., Weiss, S. T., Gaziano, J. M., Strawderman, R. L., Raiszadeh, F., Selhub, J., Tucker, K. L. Cassano, P. A. (2005). Polymorphisms in cytoplasmic serine hydroxymethyltransferase and methylenetetrahydrofolate reductase affect the risk of cardiovascular disease in Men. J. Nutr. 135:1989-1994.
Shane, B. Folate, vitamin B12 and vitaminB6. (2006) In Biochemical, Physiological, Molecular Aspects of Human Nutrition, Stipanuk, M. H., ed., second edition, pp. 693-732, Saunders, New York.
Anguera, M. C., Field, M. S., Perry, C., Ghandour, H., Chiang, E.-P., Selhub, J., Shane, B. and Stover, P. J. (2006). Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase. J. Biol. Chem. 281:18335-18342.
Nijhout, H. F., Reed, M. C., Lam, S.-L., Shane, B., Gregory, J. F. III and Ulrich, C. M. (2006). In silico experimentation with a model of hepatic mitochondrial folate metabolism. Theoret. Biol. Med. Mod. 3:40-50.
Shane, B. (2008). Folate and vitamin B12 metabolism: Overview and interaction with riboflavin, vitamin B6, and polymorphisms. In Folate and Vitamin B12 Deficiencies: Proceedings of a WHO Technical Consultation. Food Nutr. Bull. 29 S5-16.