The major research efforts of my laboratory are in the area of biochemical nutrition and, in particular, the control of one carbon metabolism. We investigate experimental nutrition problems at a basic molecular or cellular level to obtain a better understanding of factors that influence nutritional requirements and how this varies among the population. We study how genetic variation in the pathways of one carbon metabolism influence chronic disease risk and susceptibility to birth defects using humans and genetically modified animal models.
Most Recent Publications
Pangilinan, F., Molloy, A. M., Mills, J. L., Troendle, J. F., Parle-McDermott, A., Signore, C. C., O’Leary, V., Chines, P., Dolle, J., Geiler, K., Mitchell, A., VanderMeer, J., Krebs, K. M., Sanchez, A., Cornman-Homonoff, J., Stone, N., Conley, M., Kirke, P. N., Shane, B., Scott, J. M. and Brody, L. C. (2012). Evaluation of Common Genetic Variants in 82 Candidate Genes as Risk Factors for Neural Tube Defects. BMC Medical Genetics (in press).
Schaevitz, L. S., Picker, J. D., Rana, J., Kolodny, N. H., Shane, B., Berger-Sweeney, J.E. and Coyle, J.T. (2012). Glutamate carboxypeptidase II and folate deficiencies result in reciprocal protection against cognitive and social deficits in mice: implications for neurodevelopmental disorders. Dev. Neurobiol. 72:891-905. doi: 10.1002/dneu.21000.
Anderson, D. A., Woeller, C. F., Chiang, E.P., Shane, B. and Stover, P. J. (2012). SHMT anchors the de novo thymidylate synthesis pathway to the nuclear lamina for DNA synthesis. J Biol Chem. 287: 7051-7062.
Caudill, M. A., Miller, J. W., Gregory, J. F. III and Shane, B. (2012). Folate, choline, vitamin B12, and vitamin B6. In Biochemical, Physiological and Molecular Aspects of Human Nutrition, Stipanuk, M. H. and Caudill, M. A., eds., third edition, pp. 565-609, Elsevier, St. Louis.
Shane, B. (2012). Folate-responsive birth defects: of mice and women. Am. J. Clin. Nutr. 95:1-2.
Simpson JL, Bailey LB, Pietrzik K, Shane B, Holzgreve W. (2011). Micronutrients and women of reproductive potential: required dietary intake and consequences of dietary deficiency or excess. Part II--vitamin D, vitamin A, iron, zinc, iodine, essential fatty acids. J Matern Fetal Neonatal Med 24: 1-24. doi: 10.3109/14767051003678226 [doi].
Carter TC, Pangilinan F, Troendle JF, et al. (2011). Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population. Am J Med Genet A 155A:14-21. doi: 10.1002/ajmg.a.33755 [doi].
Neuhouser ML, Nijhout HF, Gregory JF III, Reed MC, James SJ, Liu A, Shane B, Ulrich CM. (2011). Mathematical modeling predicts the effect of folate deficiency and excess on cancer related biomarkers. Cancer Epidemiol. Biomark. Prev. 20: 1912-1917.
Stone N, Pangilinan F, Molloy AM, Shane B, Scott JM, Ueland PM, Mills JL, Kirke PN, Sethupathy P, Brody LC. (2011). Bioinformatic and genetic association analysis of microRNA target sites in one-carbon metabolism genes. PLoS ONE 2011;6(7):e21851.
Mills JL, Carter TC, Scott JM, Troendle JF, Gibney ER, Shane B, Kirke PN, Ueland PM, Brody LC, Molloy AM. (2011). Do high blood folate concentrations exacerbate the metabolic abnormalities in people with low vitamin B12 status? Am. J. Clin. Nutr. 94: 495-500.
Shane B. (2011). Folate status assessment history: implications for measurement of biomarkers in the National Health and Nutrition Examination Survey. Am. J. Clin. Nutr. 94: 337-42S.