John E. Casida
Research in the Environmental Chemistry and Toxicology Laboratory emphasizes pesticide mode of action and metabolism. This information is important to optimize pesticide use, improve their selectivity and environmental characteristics, and minimize the hazards of exposure for humans, domestic animals and other nontarget species. Recent research is illustrated in the publications below.
Casida, J.E., Durkin, K.A. (2017) Pesticide chemical research in toxicology: lessons from nature. Chem. Res. Toxicol., in press.
Casida, J.E. (2017) Organophosphorus xenobiotic toxicology. Annu. Rev. Pharmacol. Toxicol., in press.
Casida, J.E. (2016) Unexpected metabolic reactions and secondary targets of pesticide action. J. Agric. Food Chem. 64: 4471–4477
Casida J.E. and K.A. Durkin. (2015) Novel GABA receptorpesticide targets. Pestic. Biochem. Physiol. 121: 22-30.
Casida, J.E. (2015) Golden age of RyR and GABA-R diamide and isoxazoline insecticides: common genesis, serendipity, surprises, selectivity, and safety. Chem. Res. Toxicol. 28: 560-6.
Zhao, C., Hwang S.H., Buchholz, B. Lightstone, F.C., Carpenter, T.S., Yang, J., Hammock, B.D., Casida, J.E. (2014) The GABAa receptor target of tetramethylenedisulfotetramine. Proc. Natl. Acad. Sci. USA 111: 8607-12
Lantz, S.R, Mack, C.M., Wallace, K., Key, E.F. Shafer, T.J., Casida, J.E. (2014) Glufosinate neurotoxicity mediated in part by N-methyl-D-aspartate receptor activation. J. Agric. Food Chem. 45: 38-47
Wang, Y., Guo, L., Qi, S. Zhang, H., Liu, R., Liang, P. Casida, J.E. Shangzhong, L. (2014) Development of a fluorescence polarization binding assay for insect ryanodine receptor. Molecules 19: 4105-4114
Zhao C., Casida, J.E. (2014) Insect γ-aminobutyric acid receptors and isoxazoline insecticides: toxicological profiles relative to the binding sites of [3H]fluralaner, [3H]-4’-ethynyl-4-n-propylbicycloorthobenzoate, and [3H]avermectin. J. Agric. Food Chem. 62: 1019-1024.
Shao, X. Swenson, T. Casida, J.E. (2013) Cycloxaprid insecticide: nicotinic acetylcholine receptor binding site and metabolism. J. Agric. Food Chem. 61: 7883-7888
Lantz, S., Casida, J.E. (2013) Characterization of the transient oxaphosphetane BChE inhibitor formed from spontaneously-activated ethephon. Chem. Res. Tox. 26: 1320-1322
Swenson, T.L, Casida, J.E. (2013) Aldehyde oxidase importance in vivo in xenobiotic metabolism: imidacloprid nitroreduction in mice. Toxicol. Sci. 132:22-28
Liyasova, M.S. Schopfer, L.M. Kodani, S. Lantz, S.R., Casida, J.E., Lockridge, O. (2013) Newly observed spontaneous activation of ethephon as a butyrylcholinesterase inhibitor. Chem. Res. Toxicol. 26:422-431
Casida, J.E., Durkin, K.A. (2013) Anticholinesterase insecticide retrospective. Chem Biol. Interact. 203: 221-225
Garcia-Reynaga, P., Zhao, C. Sarpong, R. Casida, J.E. (2013) New GABA/glutamate receptor target for [3H]isoxazoline insecticide. Chem. Res. Toxicol. 26: 514-516
Honors and Awards
Member of U.S. National Academy of Sciences
Foreign Member (Fellow) of the Royal Society (United Kingdom)
Member of the European Academy of Science
Wolf Prize in Agriculture
American College of Toxicology – Distinguished Service Award
UC Berkeley Faculty Research Lecturer
College of Natural Resources – UC Berkeley – Distinguished Service Award
Edward A. Dickson Emeriti Professorship
C114 - Pesticide Chemistry and Toxicology
C148 - Pesticide Chemistry and Toxicology
199 - Supervised Independent Study and Research
299 - Nutritional Sciences and Toxicology Research