Maxwell Ruby, PhD Candidate, Daniel Nomura, PhD (recent graduate) and Carolyn Hudak (MBN graduate student) have co-authored an article published in the high-impact journal Proceedings of the National Academy of Sciences (PNAS). In their collaboration, Max, Daniel and Carolyn have found that blockade of endocannabinoid metabolism is sufficient to elicit hypertriglyceridemia through an impairment in apoE-mediated triglyceride clearance. These findings suggest a role of cannabinoid receptor 1 (CB1) activation in the pathogenesis of obesity-related hypertriglyceridemia and underscore the potential efficacy of CB1 antagonists in treating metabolic disease. Read the article.
