The Napoli lab studies regulation of the metabolon that generates the autocoid all-trans-retinoic acid (atRA) from retinol (vitamin A), and the function of atRA in in modulating intermediary metabolism (energy balance), diabesity, adipogenesis, bone health (osteoporosis) and blood glucose control. We use a combination of analytical chemistry, bioimaging, biochemistry and molecular and cell biology to determine the physiological effects of atRA.
Diabesity
We have individually knocked out two of the retinol dehydrogenases (Rdh) that catalyze the first reaction in...
