Jen-Chywan (Wally) Wang
Mechanisms of Glucocorticoid Receptor Actions
Glucocorticoids are steroid hormones that affect many aspects of mammalian physiology. Because of their potent anti-inflammatory activity glucocorticoids are also frequently used to treat various inflammatory diseases. The long-term goal of our research is to elucidate the mechanisms underlying the effects of glucocorticoids on energy homeostasis and inflammatory response. Our studies apply a combinatorial approach that includes biochemistry, genetics, chemistry and physiology, to dissect the fundamental mechanisms of physiological processes and to develop novel strategies for therapeutic intervention.
Wang JC, Gray NE, Kuo T, and Harris C, Regulation of Triglyceride Metabolism by Glucocorticoid Receptor. Cell Biosci, 2012, in press.
Koliwad SK, Gray NE, and Wang JC. Angiopoietin-like 4 (Angptl4): A Glucocorticoid-Dependent Gatekeeper of Fatty Acid Flux During Fasting. Adipocyte, 2012, in press
Kuo T, Lew M, Mayba O, Harris CA, Speed, T, and Wang JC, Genome-wide Analysis of Glucocorticoid Receptor Binding Regions in Myotubes Reveal Gene Network Modulating Insulin Signaling Pathway. PNAS, 2012, in press
Gray NE, Lam L, Yang, K, Zhou A, Koliwad, SK, Wang JC, Angiopoietin-like 4 (Angptl4) is A Physiological Mediator of Intracellular Lipolysis in Murine Adipocytes. J Biol Chem, 2012, 287:8444-8456
Yu CY, Mayba O, Lee JV, Tran J, Harris C, Speed T, and Wang JC, Genome-wide Analysis of Glucocorticoid Receptor Binding Regions in Adipocytes Reveal Gene Network Involved in Triglyceride Homeostasis, PLoS ONE, 2010, 5(12):e15188. PMID:21187916
Shipp LE, Lee JV, Yu CY, Pufall M, Zhang P, Scott DK, Wang JC, Transcriptional Regulation of Human Dual Specificity Protein Phosphatase 1 (DUSP1) Gene by Glucocorticoids, PLoS ONE, 2010, 5(10):e13754. PMID:21060794
Roohk DJ, Varady KA, Turner SM, Emson CE, Gelling RW, Shankaran M, Lindwall G, Shipp LE, Scanlan TS, Wang JC, Hellerstein MK. Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared to prednisolone. J Pharmacol Exp Ther. 2010 Jan 11. PMID:20065017
Koliwad SK, Kuo T, Shipp LE, Gray NE, Backhed F, So AY, Farese RV Jr, Wang JC. Angiopoietin-like 4 (ANGPTL4/FIAF) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism. J Biol Chem. 2009 284:25593-601