Ronald M Krauss
Adjunct Professor
About Ronald M Krauss
Ronald M. Krauss, M.D., is Senior Scientist and Dolores Jordan Endowed Chair at Children’s Hospital Oakland Research Institute, Professor of Medicine at UCSF, and Adjunct Professor of Nutritional Sciences at UC Berkeley. He is a member of the American Society for Clinical Investigation, a Fellow of the American Society of Nutrition and the American Heart Association (AHA), and a Distinguished Fellow of the International Atherosclerosis Society. He has served on the U.S. National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults, was the founding chair of the AHA Council on Nutrition, Physical Activity, and Metabolism, and is a National Spokesperson for the AHA. Dr. Krauss has also served on both the Committee on Dietary Recommended Intakes for Macronutrients and the Committee on Biomarkers of Chronic Disease of the Institute of Medicine of the National Academy of Sciences (NAS), and was a reviewer for the NAS Report on Optimizing the Process for Establishing the Dietary Guidelines for Americans. He has received numerous awards and endowed lectureships, including the AHA Scientific Councils Distinguished Achievement Award, the Centrum Center For Nutrition Science Award of the American Society for Nutrition, the Distinguished Leader in Insulin Resistance from the International Committee for Insulin Resistance, and the AHA National Award of Meritorious Achievement. He has published over 450 research articles and reviews on metabolic, genetic, dietary, and drug effects on plasma lipoproteins and risk of coronary artery disease, with over 100,000 citations of this work.
Research Description
Cardiovascular disease (CVD) is the leading cause of death in the US, and its origins begin in childhood. My research program is devoted to understanding how best to prevent CVD by early detection and management of its major risk factors, most notably elevated levels of blood cholesterol and lipoproteins. These levels are strongly influenced by diet, but there remain large gaps in our understanding of dietary approaches for optimizing CVD risk. When this risk remains high, statins and other lipid lowering drugs can provide an effective adjunct to lifestyle modification. However, there is wide individual variability in the clinical responses to both diet and drug treatments, resulting in part from genetic diversity across the population. Probing the basis for this variation can provide a path for developing and implementing therapies geared to an individual’s specific needs.
There are three complementary research activities in my program that address the overall goal of identifying dietary, pharmacologic, and genetic effects on metabolic traits related to the development and management of CVD risk:
1) I am principal investigator of a large NIH P50 grant, now in its fourth year, that integrates multiple lines of investigation to determine genetic influences on clinical efficacy of statin treatment, as well as risk for adverse effects, specifically statin-induced diabetes and myopathy. The grant comprises three research projects as well as a Clinical Core based at Kaiser Permanente of Northern California (KPNC) and an Informatics Core based at the University of Pennsylvania. The largest project, housed at CHORI and led by Dr. Marisa Medina, is using patient-derived induced pluripotent stem cells to interrogate variation in statin effects at the transcriptomic and metabolomic levels. A second project, directed by Dr. Karen Reue at UCLA, is aimed at discovering factors influencing statin effects in a large panel of genetically defined mouse models. The third project, headed by Dr. Neil Risch of UCSF, is using electronic longitudinal health and pharmacy records as well as genetic data from a cohort of nearly 100,000 patients in the KPNC system to identify factors modifying statin clinical responses in a real-world clinical practice setting. Collectively, information derived from these projects can contribute significantly to precision medicine approaches for CVD risk reduction.
2) A continuing activity of my laboratory has been the development and implementation of methodology for analysis of multiple distinct LDL subspecies, which my colleagues and I were the first to identify in human plasma. This early work led to discovery of a genetically influenced lipoprotein phenotype characterized by increased levels of small, dense LDL particles and associated with higher triglyceride and lower HDL cholesterol. Subsequently termed atherogenic dyslipidemia, this trait constitutes a central feature of the metabolic syndrome and is the characteristic dyslipidemia of type 2 diabetes. Results from a series of our studies pointing to the increased atherogenic potential of small, dense LDL particles are consistent with recent prospective evidence for the association of these particles with CVD risk. Application of this information for clinical research was enabled by development of two high resolution methods for analysis of lipoprotein subspecies that were licensed to large clinical laboratories and that have been widely utilized in clinical practice for evaluating and managing risk for CVD. In the past year, we have applied these methods to the identification of novel lipoprotein subspecies that may be involved in neurodegenerative and retinal disease, as well as CVD.
3) The third major aim of my program has been the determination of dietary macronutrient effects on atherogenic dyslipidemia. Earlier, in a series of randomized controlled dietary trials, we found that high-carbohydrate low-fat diets, at the time widely recommended for CVD prevention, resulted in the induction of the small, dense LDL phenotype in a high proportion of healthy individuals. Correspondingly, we later showed that dietary carbohydrate restriction can reverse this trait and that this effect is independent of saturated fat intake. In addition, we found that individuals with atherogenic dyslipidemia have a reduced capacity to oxidize fat, suggesting a common metabolic impairment that predisposes to both adiposity and dyslipidemia. In recent years, we have published a series of articles and reviews, including a meta-analysis of prospective cohort studies, which have pointed to the absence of an association of dietary saturated fat intake per se with CVD risk, despite the well-documented effect of saturated fat on LDL cholesterol levels. These findings, which have been confirmed by others, are consistent with our observation that the saturated fat-induced increase in LDL cholesterol is primarily attributable to an effect on larger vs. smaller LDL particles. Collectively, this work has helped support recent dietary guidelines that place a greater emphasis on limiting refined carbohydrates than fats. Finally, we have just published the results of a large NIH-funded clinical trial demonstrating that, contrary to expectations, red meat and white meat have identical effects on blood cholesterol profiles when saturated fat is held constant These results, which received considerable media attention, are likely to be considered by the 2020 U.S. Dietary Guidelines Advisory Committee. In conjunction with this project, in collaboration with investigators at the Cleveland Clinic, we showed that diets enriched in red meat, but not white meat or non-meat protein, significantly increased levels of a novel CVD biomarker derived from intestinal metabolism by resident microbes.
Recent publications:
Sun, H., Krauss, R.M., Chang, J.T. & Teng, B.B. (2018). PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction. J. Lipid Res., 59, 207-223. PMC5794417
Hoffman, T.J., Theusch, E., Haldar, T., Ranatunga, D.K., Jorgensen, E., Medina, M.W., Kvale, M.N., Kowk, P.Y., Schaefer, C., Krauss, R.M., Iribarren, C. & Risch, N. (2018). A large electronic-health-record-based genome-wide study of serum lipids. Nat. Genet., 50, 401-413. PMC5942247'
Liang, X., Yee, S.W., Chien, H.C., Chen, E.C., Luo, Q., Zou, L., Piao, M., Mifune, A., Chen, L., Calvert, M.E., King, S., Norheim, F., Abad, J., Krauss, R.M., Giacomini, K.M. (2018). Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content. PLoS Biol., 16, e2002907. PMC5919692
Wei, W.Q., Li, X., Feng, Q., Kubo, M., Kullo, I.J., Peissig, P.L., Karlson, E.W., Jarvik, G.P., Lee, M.T.M., Shang, N., Larson, E.A., Edwards, T., Shaffer, C., Mosley, J.D., Maeda, S., Horikoshi, M., Ritchie, M., Williams, M.S., Larson, E.B., Crosslin, D.R., Bland, S.T., Pacheco, J.A., Rasmussen-Torvik, L.J., Cronkite, D., Hripcsak, G., Cox, N.J., Wilke, R.A., Stein, C.M., Rotter, J.I., Momozawa, Y., Roden, D.M., Krauss, R.M. & Denny, J.C. (2018). LPA variants are associated with residual cardiovascular risk in patients receiving statins. Circulation, 138, 1839-1849. PMC6202211
Delatour, V., Clouet-Foraison, N., Gaie-Levrel, F., Marcovina, S.M., Hoofnagle, A.N., Kuklenyik, Z., Caulfield, M.P., Otvos, J.D., Krauss, R.M., Kulkami, K.R., Contois, J.H., Remaley, A.T., Vesper, H.W., Cobbaert, C.M. & Gillery, P. (2018). Comparability of lipoprotein particle number concentrations across ES-DMA, NMR, LC-MS/MS, immunoephelometry, and VAP: in search of a candidate reference measurememnt procedure for apoB and non-HDL-P standardization. Clin. Chem., 64, 17485-1495. PMID: 30087138
Kim, K., Theusch, E., Kuang, Y.L., Dose, A., Mitchel, K., Cubitt, C., Chen, Y.I., Krauss, R.M. & Medina, M.W. (2018). ZNF542P is a pseudogene associated with LDL response to simvastatin treatment. Sci. Rep., 8, 12443. PMC6102286
Oni-Orisan, A., Hoffman, T.J., Ranatunga, D., Medina, M.W., Jorgenson, E., Schaefer, C., Krauss, R.M., Iribarren, C., Risch, N. (2018). Characterization of statin low-density lipoprotein cholesterol dose-response using electronic health records in a large population-based cohort. Circ. Genom. Precis. Med. 11, e2043. PMC6214660
Vital, M., Howe, A., Bergeron, N., Krauss, R.M., Jansson, J.K., Tiedie, J.M. (2018). Metagenomic insights into the degradation of resistant starch by human gut microbiota. Appl. Environ. Micriobiol. 15, 1562-18. PMC6238065
Ligthart, S., Vaez, A., Võsa, U., Stathopoulou, M.G., de Vries, P.S., Prins, B.P., Van der Most, P.J., Tanaka, T., Naderi, E., Rose, L.M., Wu, Y., Karlsson, R., Barbalic, M., Lin, H., Pool, R., Zhu, G., Macé, A., Sidore, C., Trompet, S., Mangino, M., Sabater-Lleal, M., Kemp, J.P., Abbasi, A., Kacprowski, T., Verweij, N., Smith, A.V., Huang, T., Marzi, C., Feitosa, M.F., Lohman, K.K., Kleber, M.E., Milaneschi, Y., Mueller, C., Huq, M., Vlachopoulou, E., Lyytikäinen, L.P., Oldmeadow, C., Deelen, J., Perola, M., Zhao, J.H., Feenstra, B.; LifeLines Cohort Study, Amini, M.; CHARGE Inflammation Working Group, Lahti, J., Schraut, K.E., Fornage, M., Suktitipat, B., Chen, W.M., Li, X., Nutile, T., Malerba, G., Luan, J., Bak, T., Schork, N., Del Greco, M.F., Thiering, E., Mahajan, A., Marioni, R.E., Mihailov, E., Eriksson, J., Ozel, A.B., Zhang, W., Nethander, M., Cheng, Y.C., Aslibekyan, S., Ang, W., Gandin, I., Yengo, L., Portas, L., Kooperberg, C., Hofer, E., Rajan, K.B., Schurmann, C., den Hollander, W., Ahluwalia, T.S., Zhao, J., Draisma, H.H.M., Ford, I., Timpson, N., Teumer, A., Huang, H., Wahl, S., Liu, Y., Huang, J., Uh, H.W., Geller, F., Joshi, P.K., Yanek, L.R., Trabetti, E., Lehne, B., Vozzi, D., Verbanck, M., Biino, G., Saba, Y., Meulenbelt, I., O'Connell, J.R., Laakso, M., Giulianini, F., Magnusson, P.K.E., Ballantyne, C.M., Hottenga, J.J., Montgomery, G.W., Rivadineira, F., Rueedi, R., Steri, M., Herzig, K.H., Stott, D.J., Menni, C., Frånberg, M., St Pourcain, B., Felix, S.B., Pers, T.H., Bakker, S.J.L., Kraft, P., Peters, A., Vaidya, D., Delgado, G., Smit, J.H., Großmann, V., Sinisalo, J., Seppälä, I., Williams, S.R., Holliday, E.G., Moed, M., Langenberg, C., Räikkönen, K., Ding, J., Campbell, H., Sale, M.M., Chen, Y.I., James, A.L., Ruggiero, D., Soranzo, N., Hartman, C.A., Smith, E.N., Berenson, G.S., Fuchsberger, C., Hernandez, D., Tiesler, C.M.T., Giedraitis, V., Liewald, D., Fischer, K., Mellström, D., Larsson, A., Wang, Y., Scott, W.R., Lorentzon, M., Beilby, J., Ryan, K.A., Pennell, C.E., Vuckovic, D., Balkau, B., Concas, M.P., Schmidt, R., Mendes de Leon, C.F., Bottinger, E.P., Kloppenburg, M., Paternoster, L., Boehnke, M., Musk, A.W., Willemsen, G., Evans, D.M., Madden, P.A.F., Kähönen, M., Kutalik, Z., Zoledziewska, M., Karhunen, V., Kritchevsky, S.B., Sattar, N., Lachance, G., Clarke, R., Harris, T.B., Raitakari, O.T., Attia, J.R., van Heemst, D., Kajantie, E., Sorice, R., Gambaro, G., Scott, R.A., Hicks, A.A., Ferrucci, L., Standl, M., Lindgren, C.M., Starr, J.M., Karlsson, M., Lind, L., Li, J.Z., Chambers, J.C., Mori, T.A., de Geus, E.J.C.N., Heath, A.C., Martin, N.G., Auvinen, J., Buckley, B.M., de Craen, A.J.M., Waldenberger, M., Strauch, K., Meitinger, T., Scott, R.J., McEvoy, M., Beekman, M., Bombieri, C., Ridker, P.M., Mohlke, K.L., Pedersen, N.L., Morrison, A.C., Boomsma, D.I., Whitfield, J.B., Strachan, D.P., Hofman, A., Vollenweider, P., Cucca, F., Jarvelin, M.R., Jukema, J.W., Spector, T.D., Hamsten, A., Zeller, T., Uitterlinden, A.G., Nauck, M., Gudnason, V., Qi, L., Grallert, H., Borecki, I.B., Rotter, J.I., März, W., Wild, P.S., Lokki, M.L., Boyle, M., Salomaa, V., Melbye, M., Eriksson, J.G., Wilson, J.F., Penninx, B.W.J.H., Becker, D.M., Worrall, B.B., Gibson, G., Krauss, R.M., Ciullo, M., Zaza, G., Wareham, N.J., Oldehinkel, A.J., Palmer, L.J., Murray, S.S., Pramstaller, P.P., Bandinelli, S., Heinrich, J., Ingelsson, E., Deary, I.J., Mägi, R., Vandenput, L., van der Harst, P., Desch, K.C., Kooner, J.S., Ohlsson, C., Hayward, C., Lehtimäki, T., Shuldiner, A.R., Arnett, D.K., Beilin, L.J., Robino, A., Froguel, P., Pirastu, M., Jess, T., Koenig, W., Loos, R.J.F., Evans, D.A., Schmidt, H., Smith, G.D., Slagboom, P.E., Eiriksdottir, G., Morris, A.P., Psaty, B.M., Tracy, R.P., Nolte, I.M., Boerwinkle, E., Visvikis-Siest, S., Reiner, A.P., Gross, M., Bis, J.C., Franke, L., Franco, O.H., Benjamin, E.J., Chasman, D.I., Dupuis, J., Snieder, H., Dehghan, A & Alizadeh BZ. (2018). Genome analyses of >2000,000 individuals identify 58 loci for chronic inflammation and highlight pathways that link inflammation and complex disorders. Am. J. Hum. Genet. 103, 691-706. PMCC6218410
Lang, J.M.,Pan, C., Cantor, R.M., Tang, W.H.W., Garcia-Garcia, J.C., Kurtz, I., Hazen, S.L., Bergeron, M., Krauss, R.M. & Lusis, A.J. (2018). Impact of individual traits, saturated fat, and protein source on the gut microbiome. MBio. 9, 1604-18. PMC6299478
Lei, D., Yu, Y., Kuang, Y.L., Liu, J., Krauss, R.. & Ren, G. (2019). Single-molecule 3D imaging of human plasma intermediat-density lipoproteins reveals a polyhedral structure. Biochim. Biophys. Acta. Mol. Cell Biol. Lipids, 1864, 260-270. PMC6409128
Brower, M.A., Hai, Y., Jones, M.R., Gu, X., Chen, Y.I., Rotter, J.I, Krauss, R.M., Legro, R.S., Azziz, R., Goodarzi, M.O. (2019). Bidirectional Mendelian randomization to explore the casual relationships between body mass index and polycystic ovary syndrome. Hum. Reprod., 34, 127-136. PMCC6295958
Wang, Z., Bergeron, N., Levison, B.S., Li, X.S., Chiu, S., Jia, X., Koeth, R.A., Li, L., Wu, Y., Tang, W.H.W., Krauss, R.M & Hazen, S.L. (2019). Impact of chronic dietary red meat, white meat, or non-meat protein on trimethylamine N-oxide metabolism and renal excretion in healthy men and women. Eur. Heart J., 40, 583-594. PMC6374688
Williams, P.T., Bergeron, N., Chiu, S., Krauss, R.M. (2019). A randomized, controlled trial on the effects of almonds on lipoprotein response to a higher carbohydrate, lower fat diet in men and women with abdominal adiposity. Lipids Health Dis., 18, 1025-4. PMC6446393
Butler, A.A., Zhang, J., Price, C.A., Stevens, J.R., Graham, J.L., Stanhope, K.L., King, S., Krauss, R.M., Bremer, A.A & Havel, P.J. (2019). Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates. J. Biol. Chem., 294, 9706-9719. PMC6597842
Butler, A.A., Price, C.A., Graham, J.L., Stanhope, K.L., King, S., Hung, Y.H., Sethupathy, P., Wong, S., Hamilton, J., Krauss, R.M. Bremer, A.A. & Havel, P.J. (2019). Fructose-induced hypertriglyceridemia in rhesus macaques is attenuated with fish oil or ApoC3 RNA interference. J. Lipid Res., 60, 805-818. PMC6446715
Corey, K.E., Wilson, L.A,, Altinbas, A., Yates, K.P., Kleiner, D.E., Chung, R.T., Krauss, R.M., Chalasani, N. & NASH Clinical Research Network. (2019). Relationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial. Aliment Pharmacol. Ther, 49, 1205-1213. PMC6461513
Ramms, B., Patel, S., Nora, C., Pessentheiner, A.R., Chang, M.W., Green,, C.R., Golden, G.J., Secrest, P., Krauss, R.M., Metallo, C.M., Benner, C., Alexander, VJ., Witztum, J.L., Tsimikas, S., Esko, J.D. & Gordts, P.L.S.M. (2019). ApoC-III ASO promotes tissue LPL activity in absence of ApoE-Mediated TRL clearance. J. Lipid Res., {Epub ahead of print] PMID: 31092690
Kuang, Y.L., Munoz, A., Nalula, G., Santostefano, K.E., Sanghez, V., Sanchez, G., Terada, N., Mattis, A.N., Iacovino, M., Iribarren, C., Krauss, R.M. & Medina, M.W. (2019). Stem Cell Res., PMC6570500
Lee, S., Parekh, T., King, S.J., Reed, B., Chiu, H.C., Krauss, R.M. & Yassine, H.N. (2019). Low-density lipoprotein particle size subfractions and cerebral amyloidosis. J. Alzheimers Dis., 68, 983-990. PMID: 30883368
Bergeron, N., Chiu, S., Williams, P.T., King, S.M. & Krauss, R.M. (2019). Effects of red meat, white meat, and nonmeat protein sources on atherogenic lipoprotein measures in the context of low compared with high saturated fat intake: a randomized controlled trial. Am. J. Clin. Nutr., {Epub ahead of print] PMC6599736
Bray, G.A., Krauss, R.M., Sacks, F.M. & Qi, L. (2019). Lessons learned from the POUNDS lost study: Genetic, metabolic, and behavioral factors affecting changes in body weight, body composition, and cardiometabolic risk. Curr. Obes. Rep. [Epub ahead of print] PMID: 31214942
Hyde, P.N., Sapper, T.N., Crabtree, C.D., LaFountain, R.A., Bowling, M.L., Buga, A., Fell, B., McSwiney, F.T., Dickerson, R.M., Miller, V.J., Scandling, D., Simonetti, O.P., Phinney, S.D., Kraemer, W.J., King, S.A., Krauss, R.M. & Volek, J.S. (2019). Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss. JCI Insight, 4, 12. PMC6629108
Mach, F., Ray, K.K., Wiklund, O., Corsini, A., Catapano, A.L., Bruckert, E., De Backer, G., Hegele, R.A., Hovingh, G.K., Jacobson, T.A., Krauss, R.M., Laufs, U., Leiter, L.A., Marz, W., Nordestgaard, B.G., Raal, F.J., Roden, M., Santos, R.D., Stein, E.A., Stroes, E.S., Thompson, P.D., Tokgozoglu, L., Vladutiu, G.D., Gencer, B., Stock, J.K., Ginsberg, H.N., Chapman, M.J. & European Atherosclerosis Society Consensus Panel. (2018). Adverse effects of statin therapy: perception vs. the evidence – focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract. Eur. Heart J., 39, 2526-2539. PMC6047411
Stanhope, K.L., Goran, M.I., Bosy-Westphal, A., King, J.C., Schmidt, L.A., Schwarz, J.M., Stice, E., Sylvetsky, A.C., Turnbaugh, P.J., Bray, G.A., Gardner, C.D., Havel, P.J., Malik, V., Mason, A.E., Ravussin, E., Rosenbaum, M., Welsh, J.A., Allister-Price, C., Sigala, D.M., Greenwood, M.R.C., Astrup, A. & Krauss, R.M. (2018). Pathways and mechanisms linking dietary components to Cardiometabolic disease: thinking beyond calories. Obes. Rev., 19, 1205-1235. PMC3530989
Forohi, N.G., Krauss, R.M., Taubes, G. & Willett, W. (2018). Dietary fat and Cardiometabolic health: evidence, controversies, and consensus for guidance. BMJ, 361, k1239. PMC6053258
Astrup, A., Bertram, H.C., Bonjour, J.P., de Groot, L.C., de Oliveira Otto, M.C., Feeney, E.L., Garg, M.L., Givens, I., Fok, F.J., Krauss, R.M., Lamarche, B., Lecerf, J.M., Legrand, P., McKinley, M., Micha, R., Michalski, M.C., Mozaffarian, D., Soedamah-Muthu, S.S. (2019). BMJ, 366, I4137. PMID: 31270106
Bergeron, N., Siri-Tarino, P.W., Bray, G.A., Krauss, R.M. Nutrition and Cardiometabolic Health (textbook), CRC Press, 2018
Education
- Harvard College, AB Magna cum laude, 1964 Harvard Medical School, MD cum laude 1968
Publications
Most Recent Publications
Ruby, M.A., Nomura, D.K., Hudak, C.S., Mangravite, L.M., Chiu, S., Casida, J.E., & Krauss, R.M. (2008). Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins. Proc. Natl. Acad. Sci. USA, 105, 14561-14566. PMCID: 18794527
Chasman, D.I., Paré, G., Zee, R.Y.L., Parker, A.N., Cook, N.R., Buring, J.E., Kwiatkowski, D.J., Rose, L.M., Smith, J.D., Williams, P.T., Rieder, M.J., Rotter, J.I., Nickerson, D.A., Krauss, R.M., Miletich, J.P., & Ridker, P.M. (2008). Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and apolipoprotein B among 6382 white women in genome-wide analysis with replication. Circ. Cardiovasc. Genet., 1, 21 - 30. PMCID: 9802338
Siri-Tarino, P., Williams, P.T., Fernstrom, H.S., Rawlings, R.S., & Krauss, R.M. (2009). Reversal of small, dense LDL subclass phenotype by normalization of adiposity. Obesity, 17, 1768-75. PMCID: 19498345
Musunuru, K., Orho-Melander, M., Caulfield, M.P., Li, S., Salameh, W.A., Reitz, R.E., Berglund, G., Hedblad, B., Engstrom, G., Williams, P.T., Kathiresan, S., Melander, O. & Krauss, R.M. (2009). Ion mobility analysis of liproprotein subfractions identified three independent axes of cardiovascular risk. Arterioscler Thromb Vasc Biol., 29, 1975-80. PMCID: 19729614
Siri-Tarino, P., Sun, Q., Hu, F. & Krauss, R.M.(2010). A meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Amer. J. Clin. Nutr., 91, 535-546. PMCID: 20071648
Shin, M.-J. and Krauss, R.M. (2010). Apolipoprotein CIII bound to apoB-containing lipoproteins is associated with small, dense LDL independent of plasma triglyceride levels in healthy men. Atherosclerosis, 211:337-341. PMID: 20303494
Barber, M.J., Mangravite, L.M., Hyde, C.L., Chasman, D.I., Smith, J.D., McCarty, C.A., Li, X., Wilke, R.A., Rieder, M.J., Williams, P.T., Ridker, P.M., Chatterjee A., Rotter, J.I., Nickerson, D.A., Stephens, M. and Krauss, R.M. (2010). Genome-wide association of lipid-lowering response to statins in combined study populations. PLoS ONE, 5: e9763. PMID: 20339536, PMCID: PMC2842298
Henderson, G.C., Krauss, R.M., Fattor, J.A., Faghihnia, N., and Luke-Zeitou, M., (2010). Plasma triglyceride concentrations are rapidly reduced following individual bouts of endurance exercise in women. Eur. J. Appl. Physiol., 109:721-30. PMCID: PMC2883923, NIHMS195828.
Mangravite, L.M., Medina, M.W., Cui, J., Pressman, S., Smith, J.D., Rieder, M.J., Guo, X., Nickerson, D.A., Rotter, J.I., and Krauss, R.M. (2010). Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin. Arterioscler. Thromb., 30:1485-92. PMID: 20413733, NIHMS203361
Musunuru, K., Strong, A., Frank-Kamenetsky, M., Lee, N.E., Ahfeldt, T., Sachs, K.V., Li, X., Li, H., Kuperwasser, N., Ruda, V.M., Pirruccello, J.J., Muchmore, B., Prokunina-Olsson, L., Hall, J.L., Schadt, E.E., Morales, C.R., Lund-Katz, S., Phillips, M.C., Wong, J., Cantley W., Ejebe, K.G., Orho-Melander, M., Melander, O., Koteliansky, V., Fitzgerald, K., Krauss, R.M., Cowan, C.A., Kathiresan, S., and Rader, D.J. (2010). From Noncoding Variant to Phenotype via SORT1 at the 1p13 Cholesterol Locus. Nature, 466: 714-719. PMID: 20696566
Teslovich, T.M., Musunusru, K., Smith, A.V., Edmondson, A.C., et al. (2010). Biological, Clinical and Population Relevance of 95 Loci for Blood Lipids. Nature, 466, 707-713. PMID: 20686565
Siri-Tarino, P.W., Woods, A., Bray, G.A. and Krauss, R.M. (2010). Reversal of Small, Dense LDL Subclass Phenotype by Weight Loss Is Associated With Impaired Fat Oxidation. Obesity (Silver Spring). [Epub ahead of print]. PMID: 20559299
Ruby, M.A., Goldenson, B., Orasanu, G., Johnston, T.P., Plutzky, J. and Krauss, R.M. (2010). VLDL hydrolysis by LpL activates PPAR-(alpha) through generation of unbound fatty acids. (2010). J. Lipid. Res., 51:2275-81. PMID: 20421589
Kaddurah-Daouk, R., Baillie R.A., Zhu, H., Zeng, Z.B., Wiest, M.M., Nguyen, U.T., Watkins, S.M. and Krauss, R.M. (2010). Lipidomic analysis of variation in response to simvastatin in the Cholesterol and Pharmacogenetics Study. Metabolomics, 6:191-201. PMCID: PMC2862962
Faghihnia, N., Tsimikas, S., Miller, E.R., Witztum, J.L., Krauss, R.M. (2010). Changes in lipoprotein(a), oxidized phospholipids and LDL subclasses with a low-fat, high-carbohydrate diet. J. Lipid Res. 51:3324-30. PMID: 20713651ss.
Medina, M.W., Gao, F., Naidoo, D., Rudel, L.L., Temel, R.E., McDaniel, A.L., Marshall, S.M. and Krauss, R.M. (2011). Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake. PLoS One. 6:e19420. PMID: 21559365.
Shin, M.J., P.J. Blanche, R.S. Rawlings, H.S. Fernstrom, R.M. Krauss. Increased plasma concentration of lipoprotein (a) on a low fat, high carbohydrate diet is associated with increased plasma concentration of apolipoprotein CII bound to apoB-containing lipoproteins. Am J Clin Nutr 85:1527-32, 2007.
Mangravite, L.M., K. Dawson, R.R. Davis, J.P. Gregg, R.M. Krauss. Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and correlated with plasma triacylglycerol response. Am J Clin Nutr 86:759-767,2007.
Shin, M.J., Kanaya, A.M. and R.M. Krauss. Polymorphisms in the peroxisome proliferator activated receptor gene are associated with levels of apolipoprotein CIII and triglyceride in African-Americans but not Caucasians. Atherosclerosis 198:313-319, 2008.
Krauss, R.M., Mangravite L.M., Smith, J.D., Medina, M.W., Wang, D., Guo, X., Rieder, M.J., Simon, J.A., Hulley, S.B., Waters, D., Saad, M., Williams, P.T., Taylor, K.D., Yang, H., Nickerson, D.A. and Rotter, J.I. Variation in the Hydroxymethyl Glutaryl Coenzyme A Reductase Gene Is Associated With Racial Differences in Low-Density Lipoprotein Cholesterol Response to Simvastatin Treatment. Circulation 117:1537-1544, 2008.
Medina, M.W., Gao, F., Ruan, W., Rotter, J.I., and R.M. Krauss. Alternative splicing of HMGCR is associated with plasma LDL cholesterol response to simvastatin. Circulation [Epub ahead of print] 2008.
Honors and Awards
2014 American Heart Association Award of Meritorious Achievement (National)
2012 Margaret J. Albrink Endowed Lecture, West Virginia University School of Medicine
2012 Edwin Bierman Lecture Award, American Diabetes Association
2011 Distinguished Leader in Insulin Resistance Award, International Committee for Insulin Resistance
2011 American Heart Association Heart of Gold Ball Research Honoree
2010 Centrum Center for Nutrition Science Award, American Society for Nutrition
2009&06 Guide to America’s Top Physicians
2008 Fellow, American Society for Nutrition
2006 Distinguished Fellow, International Atherosclerosis Society
2005-now Who’s Who in the World
2005 R&D 100 Award
2004 Robert I. Levy Endowed Lecture in Lipid Metabolism, American Heart Association
2003-now Fellow, American Heart Association
2001 American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology Special Recognition Award
2001 American Heart Association Scientific Councils Distinguished Achievement Award
1986-now American Society of Clinical Investigation
1968 Alpha Omega Alpha, Harvard Medical School
1964 Phi Beta Kappa. Harvard College
1961 Detur Prize, Harvard College
Recent Teaching
NST 160